Multifaceted functions of Siva-1: more than an Indian God of Destruction.
10.1007/s13238-012-2018-5
- Author:
Yide MEI
1
;
Mian WU
Author Information
1. Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. meiyide@ustc.edu.cn
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Apoptosis Regulatory Proteins;
metabolism;
Feedback, Physiological;
Humans;
Models, Biological;
Neoplasm Metastasis;
Neoplasms;
pathology;
Proto-Oncogene Proteins c-mdm2;
metabolism;
Signal Transduction;
Tumor Suppressor Protein p53;
metabolism
- From:
Protein & Cell
2012;3(2):117-122
- CountryChina
- Language:English
-
Abstract:
Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppressing tumor metastasis, and their potential implications.
