Hippo pathway in intestinal homeostasis and tumorigenesis.
10.1007/s13238-012-2913-9
- Author:
Lanfen CHEN
1
;
Funiu QIN
;
Xianming DENG
;
Joseph AVRUCH
;
Dawang ZHOU
Author Information
1. State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China. chenlanfen@xmu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Transformation, Neoplastic;
Drosophila;
Drosophila Proteins;
metabolism;
Homeostasis;
Intestinal Mucosa;
metabolism;
Intracellular Signaling Peptides and Proteins;
metabolism;
Nuclear Proteins;
metabolism;
Protein-Serine-Threonine Kinases;
metabolism;
Regeneration;
Signal Transduction
- From:
Protein & Cell
2012;3(4):305-310
- CountryChina
- Language:English
-
Abstract:
The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death. Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis. Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis, and the crosstalk between the Hippo signaling pathway and other major signaling pathways, i.e. Wnt, Notch and Jak/Stat signaling pathways in intestinal compartment.
