The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.
10.1007/s13238-012-2021-x
- Author:
Shuai WANG
1
;
Jing LONG
;
Chun-fu ZHENG
Author Information
1. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
- Publication Type:Journal Article
- MeSH:
Herpes Simplex;
virology;
Herpesvirus 1, Human;
genetics;
physiology;
Humans;
Immediate-Early Proteins;
metabolism;
Intranuclear Inclusion Bodies;
metabolism;
virology;
Leukemia, Promyelocytic, Acute;
metabolism;
Ubiquitin-Protein Ligases;
metabolism;
Virus Latency;
physiology
- From:
Protein & Cell
2012;3(5):372-382
- CountryChina
- Language:English
-
Abstract:
Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small nuclear sub-structures, contribute to the repression of HSV-1 infection in the absence of functional ICP0. In this review, we discuss the fundamentals of the interaction between ICP0 and PML NBs, suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.
