Mitochondria in the pathogenesis of diabetes: a proteomic view.
10.1007/s13238-012-2043-4
- Author:
Xiulan CHEN
1
;
Shasha WEI
;
Fuquan YANG
Author Information
1. Key Laboratory of Protein and Peptide Pharmaceuticals and Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
- Publication Type:Journal Article
- MeSH:
Adipose Tissue;
metabolism;
Diabetes Complications;
Diabetes Mellitus;
metabolism;
pathology;
Humans;
Insulin;
metabolism;
Insulin-Secreting Cells;
cytology;
metabolism;
Liver;
metabolism;
Mitochondria;
metabolism;
Muscle, Skeletal;
metabolism;
Proteome;
metabolism;
Proteomics
- From:
Protein & Cell
2012;3(9):648-660
- CountryChina
- Language:English
-
Abstract:
Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia due to absolute or relative lack of insulin. Though great efforts have been made to investigate the pathogenesis of diabetes, the underlying mechanism behind the development of diabetes and its complications remains unexplored. Cumulative evidence has linked mitochondrial modification to the pathogenesis of diabetes and its complications and they are also observed in various tissues affected by diabetes. Proteomics is an attractive tool for the study of diabetes since it allows researchers to compare normal and diabetic samples by identifying and quantifying the differentially expressed proteins in tissues, cells or organelles. Great progress has already been made in mitochondrial proteomics to elucidate the role of mitochondria in the pathogenesis of diabetes and its complications. Further studies on the changes of mitochondrial protein specifically post-translational modifications during the diabetic state using proteomic tools, would provide more information to better understand diabetes.
