Functional regulation of monocyte-derived dendritic cells by microRNAs.
10.1007/s13238-012-0042-0
- Author:
Yifan ZHAN
1
;
Li WU
Author Information
1. The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia. zhan@wehi.edu.au
- Publication Type:Journal Article
- MeSH:
Animals;
Antigen Presentation;
genetics;
Cell Differentiation;
Cytokines;
genetics;
metabolism;
Dendritic Cells;
metabolism;
physiology;
Humans;
Inflammation;
immunology;
pathology;
MicroRNAs;
metabolism;
physiology;
RNA Interference
- From:
Protein & Cell
2012;3(7):497-507
- CountryChina
- Language:English
-
Abstract:
Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a "double-edge" sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.
