Aptamer-based molecular imaging.
10.1007/s13238-012-2072-z
- Author:
Tianjiao WANG
1
;
Judhajeet RAY
Author Information
1. Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA. tjwang@iastate.edu
- Publication Type:Journal Article
- MeSH:
Animals;
Aptamers, Nucleotide;
genetics;
metabolism;
Base Sequence;
Biosensing Techniques;
Humans;
Molecular Imaging;
methods
- From:
Protein & Cell
2012;3(10):739-754
- CountryChina
- Language:English
-
Abstract:
Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living organisms. Aptamers, short single-stranded nucleic acids selected in vitro to bind a broad range of target molecules avidly and specifically, are ideal molecular recognition elements for probe development in molecular imaging. This review summarizes the current state of aptamer-based biosensor development (probe design and imaging modalities) and their application in imaging small molecules, nucleic acids and proteins mostly in a cellular context with some animal studies. The article is concluded with a brief discussion on the perspective of aptamer-based molecular imaging.
