Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos.
10.1007/s13238-015-0177-x
- Author:
Si WANG
1
;
Fei YI
;
Jing QU
Author Information
1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
- Publication Type:Journal Article
- MeSH:
Animals;
DNA, Mitochondrial;
genetics;
Embryo, Mammalian;
metabolism;
Genome;
Germ Cells;
metabolism;
Humans;
Mitochondrial Diseases;
genetics;
therapy;
RNA Editing;
genetics
- From:
Protein & Cell
2015;6(7):472-475
- CountryChina
- Language:English
-
Abstract:
Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases.
