Thermodynamics of ABC transporters.
10.1007/s13238-015-0211-z
- Author:
Xuejun C ZHANG
1
;
Lei HAN
2
;
Yan ZHAO
2
Author Information
1. National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. zhangc@ibp.ac.cn.
2. National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
- Publication Type:Journal Article
- Keywords:
ABC transporters;
differential-binding energy;
elastic conformational energy;
energy-coupling
- MeSH:
ATP-Binding Cassette Transporters;
physiology;
Adenosine Triphosphate;
metabolism;
Animals;
Humans;
Models, Theoretical;
Thermodynamics
- From:
Protein & Cell
2016;7(1):17-27
- CountryChina
- Language:English
-
Abstract:
ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the discussion. We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well.
