Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer.

Haiyang Zhang; Jingjing Duan; Yanjun QU; Ting Deng; Rui Liu; Le Zhang; Ming Bai; Jialu LI; Tao Ning; Shaohua GE; Xia Wang; Zhenzhen Wang; Qian Fan; Hongli LI; Guoguang Ying; Dingzhi Huang; Yi BA

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Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer.

Author: Haiyang ZHANG ¹ ; Jingjing DUAN ¹ ; Yanjun QU ¹ ; Ting DENG ¹ ; Rui LIU ¹ ; Le ZHANG ¹ ; Ming BAI ¹ ; Jialu LI ² ; Tao NING ¹ ; Shaohua GE ¹ ; Xia WANG ¹ ; Zhenzhen WANG ³ ; Qian FAN ¹ ; Hongli LI ¹ ; Guoguang YING ¹ ; Dingzhi HUANG ⁴ ; Yi BA ⁵
Author Information

1. Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, 300060, China.
2. Department of Gastroenterology, Tianjin First Center Hospital, Tianjin, 300192, China.
3. Changchun GeneScience Pharmaceuticals Co., Ltd, Changchun, 130012, China.
4. Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, 300060, China. dingzhih72@163.com.
5. Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, 300060, China. bayi@tjmuch.com.
Publication Type:Journal Article
Keywords: BCL2L11; cell apoptosis; gastric cancer; miR-24; migration; proliferation; tumorigenesis
MeSH: Animals; Apoptosis; genetics; Apoptosis Regulatory Proteins; deficiency; genetics; Base Sequence; Bcl-2-Like Protein 11; Cell Line, Tumor; Cell Movement; genetics; Cell Proliferation; genetics; Down-Regulation; genetics; Gene Silencing; Male; Membrane Proteins; deficiency; genetics; Mice; MicroRNAs; genetics; Proto-Oncogene Proteins; deficiency; genetics; Rats; Stomach Neoplasms; genetics; pathology
From: Protein & Cell 2016;7(2):141-151
CountryChina
Language:English
Abstract: Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3'UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.