Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride.
10.1007/s13238-016-0256-7
- Author:
Linlin ZHAO
1
;
Shuqing WANG
2
;
Lingyu DU
1
;
Jyoti DEV
3
;
Liujuan ZHOU
1
;
Zhijun LIU
1
;
James J CHOU
4
;
Bo OUYANG
5
Author Information
1. National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China.
2. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
4. National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China. james_chou@hms.harvard.edu.
5. National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China. ouyang@sibcb.ac.cn.
- Publication Type:Letter
- MeSH:
Amiloride;
analogs & derivatives;
chemistry;
metabolism;
Binding Sites;
Genotype;
Hepacivirus;
genetics;
metabolism;
Humans;
Magnetic Resonance Spectroscopy;
Molecular Dynamics Simulation;
Protein Structure, Tertiary;
Viral Proteins;
antagonists & inhibitors;
metabolism
- From:
Protein & Cell
2016;7(4):300-304
- CountryChina
- Language:English
