Retinoic acid inducible gene-I, more than a virus sensor.
10.1007/s13238-011-1045-y
- Author:
Feng LIU
1
;
Jun GU
Author Information
1. National Key Laboratory of Protein Engineering and Plant Gene Engineering, LSC, Peking University, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Antiviral Agents;
chemistry;
DEAD Box Protein 58;
DEAD-box RNA Helicases;
chemistry;
metabolism;
physiology;
Humans;
Inflammation;
metabolism;
Interferon Regulatory Factor-3;
metabolism;
NF-kappa B;
metabolism;
RNA Viruses;
metabolism;
RNA, Double-Stranded;
metabolism;
Signal Transduction
- From:
Protein & Cell
2011;2(5):351-357
- CountryChina
- Language:English
-
Abstract:
Retinoic acid inducible gene-I (RIG-I) is a caspase recruitment domain (CARD) containing protein that acts as an intracellular RNA receptor and senses virus infection. After binding to double stranded RNA (dsRNA) or 5'-triphosphate single stranded RNA (ssRNA), RIG-I transforms into an open conformation, translocates onto mitochondria, and interacts with the downstream adaptor mitochondrial antiviral signaling (MAVS) to induce the production of type I interferon and inflammatory factors via IRF3/7 and NF-κB pathways, respectively. Recently, accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events, such as inflammation and inflammation related diseases, cell proliferation, apoptosis and even senescence. Here we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields.
