Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention.
10.1007/s13238-011-1100-8
- Author:
Wanisa SALAEMAE
1
;
Al AZHAR
;
Grant W BOOKER
;
Steven W POLYAK
Author Information
1. School of Molecular and Biomedical Sciences, University of Adelaide, South Australia 5005, Australia.
- Publication Type:Journal Article
- MeSH:
Biotin;
biosynthesis;
Carbon-Carbon Ligases;
metabolism;
Carrier Proteins;
metabolism;
Cell Membrane;
metabolism;
Coenzymes;
metabolism;
Fatty Acids;
biosynthesis;
Genes, Bacterial;
Genome, Bacterial;
Metabolic Networks and Pathways;
Molecular Structure;
Mycobacterium Infections;
microbiology;
Mycobacterium tuberculosis;
genetics;
metabolism;
pathogenicity;
physiology;
Virulence
- From:
Protein & Cell
2011;2(9):691-695
- CountryChina
- Language:English
-
Abstract:
Biotin is an important micronutrient that serves as an essential enzyme cofactor. Bacteria obtain biotin either through de novo synthesis or by active uptake from exogenous sources. Mycobacteria are unusual amongst bacteria in that their primary source of biotin is through de novo synthesis. Here we review the importance of biotin biosynthesis in the lifecycle of Mycobacteria. Genetic screens designed to identify key metabolic processes have highlighted a role for the biotin biosynthesis in bacilli growth, infection and survival during the latency phase. These studies help to establish the biotin biosynthetic pathway as a potential drug target for new anti-tuberculosis agents.
