Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis.
10.1007/s13238-011-1095-1
- Author:
Hui DAI
1
;
Xiao-Ming GAO
Author Information
1. Department of Immunology, Peking University Health Science Center, Peking University, Beijing 100083, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Arthritis, Rheumatoid;
blood;
immunology;
Case-Control Studies;
Enzyme-Linked Immunosorbent Assay;
Female;
Glucans;
immunology;
Humans;
Immunoglobulin A;
analysis;
blood;
Immunoglobulin G;
analysis;
blood;
Immunoglobulin M;
analysis;
blood;
Lupus Erythematosus, Systemic;
blood;
immunology;
Male;
Middle Aged;
ROC Curve;
Sensitivity and Specificity;
Serologic Tests;
Young Adult
- From:
Protein & Cell
2011;2(9):739-744
- CountryChina
- Language:English
-
Abstract:
This study was undertaken to investigate whether levels of anti-alpha-1, 6-glucan antibodies in human sera correlate with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Serum samples were collected from patients with SLE (n = 30), RA (n = 30) and healthy adult volunteers. IgG, IgA and IgM levels against alpha-1, 6-glucan were measured using enzyme linked immunosorbent assays. Anti-alpha-1, 6-glucan IgG prevalence was raised in patients with active SLE (73.3%) and RA (60%) compared with healthy controls (13.3%). Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor (r = 0.642; p < 0.05) in RA patients or anti-nuclear antibodies (r = 0.675; p < 0.05) in SLE patients was observed. No significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different groups. We conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.
