The minor collagens in articular cartilage.
10.1007/s13238-017-0377-7
- Author:
Yunyun LUO
1
;
Dovile SINKEVICIUTE
2
;
Yi HE
2
;
Morten KARSDAL
2
;
Yves HENROTIN
3
;
Ali MOBASHERI
4
;
Patrik ÖNNERFJORD
5
;
Anne BAY-JENSEN
2
Author Information
1. Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark. yyl@nordicbio.com.
2. Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark.
3. Bone and Cartilage Research Unit, Institute of Pathology, Level 5, Arthropole Liège, University of Liège, CHU Sart-Tilman, 4000, Liège, Belgium.
4. Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
5. Department of Clinical Sciences, Medical Faculty, Lund University, Lund, Sweden.
- Publication Type:Journal Article
- Keywords:
arthritis;
biomarker;
collagen
- MeSH:
Aggrecans;
chemistry;
genetics;
metabolism;
Animals;
Biomarkers;
metabolism;
Cartilage, Articular;
chemistry;
metabolism;
pathology;
Collagen;
chemistry;
classification;
genetics;
metabolism;
Extracellular Matrix Proteins;
chemistry;
genetics;
metabolism;
Gene Expression;
Humans;
Osteoarthritis;
diagnosis;
genetics;
metabolism;
pathology;
Protein Isoforms;
chemistry;
classification;
genetics;
metabolism
- From:
Protein & Cell
2017;8(8):560-572
- CountryChina
- Language:English
-
Abstract:
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.
