Cellular microparticles and pathophysiology of traumatic brain injury.
10.1007/s13238-017-0414-6
- Author:
Zilong ZHAO
1
;
Yuan ZHOU
1
;
Ye TIAN
1
;
Min LI
2
;
Jing-Fei DONG
3
;
Jianning ZHANG
4
Author Information
1. Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
2. Institute of Pathology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
3. BloodWorks Northwest Research Institute, Seattle, WA, 98102, USA. jfdong@BloodWorksNW.org.
4. Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China. jianningzhang@hotmail.com.
- Publication Type:Journal Article
- Keywords:
cellular microparticles;
coagulopathy;
inflammation;
traumatic brain injury
- MeSH:
Animals;
Astrocytes;
metabolism;
pathology;
Biological Transport;
Blood Coagulation Factors;
genetics;
metabolism;
Brain;
metabolism;
pathology;
physiopathology;
Brain Injuries, Traumatic;
genetics;
metabolism;
pathology;
physiopathology;
Cell-Derived Microparticles;
chemistry;
metabolism;
pathology;
Cytokines;
blood;
genetics;
Disease Models, Animal;
Disseminated Intravascular Coagulation;
genetics;
metabolism;
pathology;
physiopathology;
Gene Expression Regulation;
Humans;
Microglia;
metabolism;
pathology;
Neurons;
metabolism;
pathology;
Signal Transduction
- From:
Protein & Cell
2017;8(11):801-810
- CountryChina
- Language:English
-
Abstract:
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The finding that cellular microparticles (MPs) generated by injured cells profoundly impact on pathological courses of TBI has paved the way for new diagnostic and therapeutic strategies. MPs are subcellular fragments or organelles that serve as carriers of lipids, adhesive receptors, cytokines, nucleic acids, and tissue-degrading enzymes that are unique to the parental cells. Their sub-micron sizes allow MPs to travel to areas that parental cells are unable to reach to exercise diverse biological functions. In this review, we summarize recent developments in identifying a casual role of MPs in the pathologies of TBI and suggest that MPs serve as a new class of therapeutic targets for the prevention and treatment of TBI and associated systemic complications.
