IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes.
10.1007/s13238-017-0425-3
- Author:
Cécile APERT
1
;
Paola ROMAGNOLI
2
;
Joost P M VAN MEERWIJK
3
Author Information
1. CPTP, Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France.
2. CPTP, Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France. Paola.Romagnoli@inserm.fr.
3. CPTP, Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France. Joost.van-Meerwijk@inserm.fr.
- Publication Type:Journal Article
- Keywords:
IL-15;
IL-2;
differentiation;
regulatory T cells;
thymus
- MeSH:
Animals;
Cell Differentiation;
genetics;
Cytokines;
immunology;
Forkhead Transcription Factors;
genetics;
immunology;
Gene Expression Regulation;
Immune Tolerance;
genetics;
Interleukin-15;
genetics;
immunology;
Interleukin-2;
genetics;
immunology;
Mice;
Receptors, Antigen, T-Cell;
genetics;
immunology;
T-Lymphocytes, Regulatory;
immunology;
Transforming Growth Factor beta;
genetics;
immunology
- From:
Protein & Cell
2018;9(4):322-332
- CountryChina
- Language:English
-
Abstract:
Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15. The more recently appreciated involvement of TGF-β in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process.
