RIG-I: a multifunctional protein beyond a pattern recognition receptor.
10.1007/s13238-017-0431-5
- Author:
Xiao-Xiao XU
1
;
Han WAN
1
;
Li NIE
1
;
Tong SHAO
1
;
Li-Xin XIANG
2
;
Jian-Zhong SHAO
3
Author Information
1. Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
2. Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China. xianglx@zju.edu.cn.
3. Key Laboratory for Cell and Gene Engineering of Zhejiang Province, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China. shaojz@zju.edu.cn.
- Publication Type:Journal Article
- Keywords:
RIG-I;
cancer;
endogenous RNA;
immunity;
viral RNA
- MeSH:
Animals;
DEAD Box Protein 58;
genetics;
metabolism;
Mice;
RNA, Viral;
genetics;
metabolism;
STAT1 Transcription Factor;
genetics;
metabolism;
Signal Transduction;
genetics;
physiology
- From:
Protein & Cell
2018;9(3):246-253
- CountryChina
- Language:English
-
Abstract:
It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs. However, recent studies showed that RIG-I participates in other various cellular activities by sensing endogenous RNAs under different circumstances. For example, RIG-I facilitates the therapy resistance and expansion of breast cancer cells and promotes T cell-independent B cell activation through interferon signaling activation by recognizing non-coding RNAs and endogenous retroviruses in certain situations. While in hepatocellular carcinoma and acute myeloid leukemia, RIG-I acts as a tumor suppressor through either augmenting STAT1 activation by competitively binding STAT1 against its negative regulator SHP1 or inhibiting AKT-mTOR signaling pathway by directly interacting with Src respectively. These new findings suggest that RIG-I plays more diverse roles in various cellular life activities, such as cell proliferation and differentiation, than previously known. Taken together, the function of RIG-I exceeds far beyond that of a pattern recognition receptor.
