Highly efficient and precise base editing in discarded human tripronuclear embryos.

Author: Guanglei LI ¹ ; Yajing LIU ² ; Yanting ZENG ¹ ; Jianan LI ² ; Lijie WANG ² ; Guang YANG ² ; Dunjin CHEN ¹ ; Xiaoyun SHANG ³ ; Jia CHEN ² ; Xingxu HUANG ⁴ ; Jianqiao LIU ⁵
Author Information

1. Department of Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
2. School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
3. Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, China.
4. School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. huangxx@shanghaitech.edu.cn.
5. Department of Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. liujqssz@gzhmu.edu.cn.
Publication Type:Letter
MeSH: CRISPR-Cas Systems; Embryo, Mammalian; Gene Editing; methods; HEK293 Cells; Humans; Polycomb Repressive Complex 1; genetics; Zygote
From: Protein & Cell 2017;8(10):776-779
CountryChina
Language:English