Highly efficient base editing in human tripronuclear zygotes.
10.1007/s13238-017-0459-6
- Author:
Changyang ZHOU
1
;
Meiling ZHANG
2
;
Yu WEI
1
;
Yidi SUN
3
;
Yun SUN
2
;
Hong PAN
1
;
Ning YAO
2
;
Wanxia ZHONG
2
;
Yixue LI
3
;
Weiping LI
4
;
Hui YANG
5
;
Zi-Jiang CHEN
6
Author Information
1. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
2. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
3. College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
4. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. liweiping@renji.com.
5. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. huiyang@ion.ac.cn.
6. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. chenzijiang@hotmail.com.
- Publication Type:Letter
- MeSH:
APOBEC-1 Deaminase;
genetics;
Clustered Regularly Interspaced Short Palindromic Repeats;
Codon, Terminator;
Gene Editing;
methods;
Humans;
Zygote;
beta-Globins;
genetics
- From:
Protein & Cell
2017;8(10):772-775
- CountryChina
- Language:English
