Progress in the mechanism of Müller cells in the formation and prognosis of idiopathic macular hole
10.3980/j.issn.1672-5123.2019.12.14
- VernacularTitle:Müller细胞在特发性黄斑裂孔形成及愈合机制中的研究进展
- Author:
Zi-Yu Zhang
1
,
2
,
3
,
4
Author Information
1. 1Xi'
2. an Medical University, Xi'
3. an 710021, Shaanxi Province,China
4. 2Department of Ophthalmology, Hanzhong 3201 Hospital, Hanzhong 723200, Shaanxi Province, China
- Publication Type:Journal Article
- Keywords:
idiopathic macular hole;
internal limiting membrane;
glial cells;
Müller cells
- From:
International Eye Science
2019;19(12):2061-2063
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic macular hole(IMH)refers to the defect of retinal nerve epidermis in macular area with unknown pathogenesis. As present, pars plana vitrectomy combined with internal limiting membrane peeling has become a normal operation for the treatment of IMH, which enables most IMH patients to achieve anatomic healing, however, it is still unclear about the healing mechanism. The role of the glial cell activation in the pathological process of nervous system injury and disease has paid more and more attention. Nearly all the injuries and diseases of nervous system(including retina)are accompanied by the activation of glial cells; and Müller cells are the main type of glial cells in the human retina. In terms of anatomy and function, they are widely related to the cell bodies and processes of neurons in all layers of the retina, and play a supporting, nutritional and information transmission role in neurons. Numerous studies have shown that the activation and proliferation of Müller cells play a leading role in closed MH. It is reviewed in this paper that the role and its related mechanisms of Müller cells in the formation and healing of IMH.
- Full text:201912014.pdf
