Progress of intestinal flora in colorectal cancer
10.3760/cma.j.issn.1006-9801.2019.06.017
- VernacularTitle:肠道菌群在结直肠癌中的研究进展
- Author:
Bao YUAN
1
;
Chaoqun MA
Author Information
1. 南京中医药大学江阴附属医院肛肠科 214400
- Keywords:
Colorectal neoplasms;
Enterobactin;
Disorders of Environmental Origin;
Inflammation
- From:
Cancer Research and Clinic
2019;31(6):425-428
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of colorectal cancer is related to genetic and environmental factors. Chronic inflammation of the intestinal mucosa is one of the most important factors in environmental factors. In inflammation factors, Intestinal flora plays a role in bridging and inducing intervention. Environmental changes disrupt the homeostasis of intestinal flora, intestinal flora maladjustment occurred, bacteria induces intestinal mucosal inflammation. The pathogenic bacterium adheres to the surface of the intestinal mucosa, it produces cytotoxic and genotoxic products, intestinal epithelial cells undergo genetic damage. The synthesis and metabolites of bacteria also control the occurrence of colorectal tumor process. This process leads to the progression of inflammation to cancer. This article reviews the process of intestinal flora mediated from inflammation to carcinogenesis, and the latest progress in related pathogenic bacteria, and proposes that the intestinal flora can be adjusted and targeted removal of the conditional pathogenic bacteria, and achieve the goal of cancer prevention. The relationship between intestinal flora, intestinal inflammation and colorectal cancer is reviewed.
