Correlation of metallothionein-2A, E-cadherin and cyclin E with biochemical recurrence in prostate cancer
10.3760/cma.j.issn.1006-9801.2019.06.008
- VernacularTitle:金属硫蛋白2A、E钙黏蛋白及细胞周期蛋白E与前列腺癌生化复发的相关性
- Author:
Wei CHENG
1
;
Ding MA
;
Bin YANG
;
Jiwen SHANG
;
Zhenguo MI
;
Yangang ZHANG
Author Information
1. 山西医学科学院 山西大医院泌尿外科
- Keywords:
Prostatic neoplasms;
Metallothionein 2A;
Cadherins;
Cyclin E;
Biochemical recurrence;
Microchip analytical procedures
- From:
Cancer Research and Clinic
2019;31(6):395-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of metallothionein-2A (MT-2A), E-cadherin, interleukin-6 (IL-6), cyclin E, proliferating cell nuclear antigen (PCNA) and bcl-2 in prostate cancer tissues and their correlation with biochemical recurrence of prostate cancer. Methods Tissue specimens from 128 cases of prostate cancer who underwent radical prostatectomy in Shanxi Dayi Hospital from October 2012 to October 2017 were processed and transferred into tissue microarrays, the clinicopathological parameters of patients were also recorded. The expression levels of MT-2A, E-cadherin, IL-6, cyclin E, PCNA and bcl-2 were detected by immunohistochemical avidin-biotin complex (ABC) staining. The correlation between different molecular markers and biochemical recurrence of prostate cancer was analyzed. Results The biochemical recurrence rate of 128 patients with prostate cancer was 30.5％ (39/128). The biochemical recurrence rates of low-risk, intermediate-risk and high-risk prostate cancer patients were 14.8％(8/54), 38.7％(24/62) and 58.3％ (7/12), respectively. The risk classification and pathological T stage of patients with prostate cancer were associated with the expressions of MT-2A, cyclin E, IL-6 and E-cadherin (all P< 0.05). Multivariate Cox risk model showed that the high risk classification (HR= 1.81, 95％CI 1.56-2.19, P=0.042), MT-2A positive expression (HR= 2.01, 95％CI 1.08-3.15, P= 0.005), cyclin E positive expression (HR= 1.79, 95％CI 1.08-2.21, P= 0.042) and E-cadherin negative expression (HR= 1.92, 95％ CI 1.22-2.45, P= 0.020) were the independent risk factors for biochemical recurrence of prostate cancer. Conclusion The expression of MT-2A, cyclin E and E-cadherin may serve as independent predictors for biochemical recurrence of prostate cancer.
