Expressions of osteopontin, matrix metalloproteinase 2 and vascular endothelial growth factor in gastric cancer and their prognostic value
10.3760/cma.j.issn.1006-9801.2019.06.007
- VernacularTitle:骨桥蛋白、基质金属蛋白酶2和血管内皮生长因子在胃癌组织中的表达及其预后价值
- Author:
Weiwei YU
1
;
Hai WANG
;
Jie ZHANG
;
Jinfeng MIAO
;
Yan KONG
;
Fanjie QU
Author Information
1. 大连市第三人民医院肿瘤一病房 116033
- Keywords:
Gastric neoplasms;
Osteopontin;
Matrix metalloproteinase;
Vascular endothelial growth factor;
Prognosis;
Immunohistochemistry
- From:
Cancer Research and Clinic
2019;31(6):390-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expressions of osteopontin (OPN), matrix metalloproteinase 2 (MMP-2) and vascular endothelial growth factor (VEGF) in gastric cancer and the poor prognosis of gastric cancer patients. Methods A total of 35 patients with gastric cancer after radical gastrectomy from January 2014 to March 2015 in Dalian Third People ' s Hospital were retrospectively analyzed. The expressions of OPN, MMP-2 and VEGF in gastric cancer tissues and adjacent normal tissues were detected by immunohistochemical SP staining. The relationship between the expressions of OPN, MMP-2 and VEGF and the poor prognosis of gastric cancer patients was analyzed. Results The positive expression rates of OPN, MMP-2 and VEGF in postoperative pathological tissues of gastric cancer were 80.0％ (28/35), 77.1％(27/31) and 88.6％(31/35), respectively. OPN expression was associated with vascular invasion, lymph node metastasis, degree of differentiation, degree of invasion, and Lauren classification (all P< 0.05). MMP-2 expression was associated with vascular invasion, lymph node metastasis, and degree of invasion (all P<0.05). VEGF expression was associated with vascular invasion, lymph node metastasis, degree of invasion, and Lauren classification (all P< 0.05). OPN, VEGF and MMP-2 had synergistic effects in the invasion and metastasis of gastric cancer, and the expressions of them were positively correlated (all P< 0.05). The sensitivity of combined detection of OPN, VEGF and MMP-2 (87.5％) was higher than the sensitivity of individual detection (68.8％, 62.5％ and 56.3％) (P< 0.05). Conclusions OPN, MMP-2 and VEGF expressions are closely related to the poor prognosis of gastric cancer patients, and have synergistic effects in the invasion and metastasis of gastric cancer. The combined detection of OPN, MMP-2 and VEGF may have a more accurate prediction of the prognosis of gastric cancer.
