Expressions of Notch receptors in gastric cancer and their clinical significances
10.3760/cma.j.issn.1006-9801.2019.06.005
- VernacularTitle:Notch受体在胃癌中的表达及其临床意义
- Author:
Yuejun LI
1
;
Lingzhi LIU
;
Hongyu LI
;
Haihui HE
;
Ming CHEN
Author Information
1. 湖南中医药大学第三附属医院肿瘤科
- Keywords:
Gastric neoplasms;
Notch receptors;
Immunohistochemistry
- From:
Cancer Research and Clinic
2019;31(6):381-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Notch receptors and its relationship with clinicopathological features and prognosis in gastric cancer tissues. Methods Immunohistochemical SP method was used to detect the expression levels of Notch1, Notch2, Notch3 and Notch4 corresponding receptors in 45 patients with gastric cancer from January 2014 to May 2015 in the Third Affiliated Hospital of Hunan University of Traditional Chinese Medicine. The correlation between expression levels of Notch receptors and lymph node metastasis, TNM staging, disease-free survival (DFS) and overall survival (OS) were analyzed. Results Notch1, Notch2, Notch3 and Notch4 corresponding receptors were mainly distributed in the cytoplasm, and the positive expression rates in gastric cancer tissues were 93.3％ (42/45), 86.7％ (39/45), 80.0％ (36/45), and 77.8％ (35/45), which were higher than those in adjacent tissues [31.1％ (14/45), 24.4％(11/45), 40.0％ (18/45), and 46.7％ (21/45)], and the differences were statistically significant (all P< 0.05). There was no correlation between the expression of Notch1, Notch2, Notch3 and Notch4 corresponding receptors and lymph node metastasis, TNM staging, DFS and OS in gastric cancer tissues (all P> 0.05). Conclusion Notch receptors are highly expressed in gastric cancer tissues, and have no correlation with lymph node metastasis, TNM staging, DFS and OS of patients after surgery.
