Association between Helicobacter pylori Infection and Cerebral Small Vessel Disease.
10.4082/kjfm.2015.36.5.227
- Author:
Soo Hyun JANG
1
;
Hyejin LEE
;
Jun Suk KIM
;
Hyun Jung PARK
;
Su Min JEONG
;
Sang Hyun LEE
;
Hyun Ho KIM
;
Jin Ho PARK
;
Dong Wook SHIN
;
Jae Moon YUN
;
Belong CHO
;
Hyung Min KWON
Author Information
1. Department of Family Medicine & Health Promotion Center, Seoul National University Hospital, Seoul, Korea. jie2128@gmail.com
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Small Vessel Disease;
Silent Brain Infarction;
Cerebral Microbleeds
- MeSH:
Aged;
Body Mass Index;
Brain;
Brain Infarction;
Cerebral Small Vessel Diseases*;
Diabetes Mellitus;
Drinking;
Dyslipidemias;
Gastritis, Atrophic;
Health Promotion;
Helicobacter pylori*;
Helicobacter*;
Humans;
Hypertension;
Inflammation;
Logistic Models;
Magnetic Resonance Imaging;
Odds Ratio;
Risk Factors;
Seoul;
Smoke;
Smoking;
Stroke
- From:Korean Journal of Family Medicine
2015;36(5):227-232
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Small vessel disease is an important cause of cerebrovascular diseases and cognitive impairment in the elderly. There have been conflicting results regarding the relationship between Helicobacter pylori infection and ischemic stroke. This study aimed to examine the association between H. pylori infection and cerebral small vessel disease. METHODS: The study included 1,117 patients who underwent brain magnetic resonance imaging and H. pylori identification between 2005 and 2013 at Health Promotion Center, Seoul National University Hospital. Multivariable logistic regression analysis was used to assess the association between H. pylori infection and small vessel disease with adjustment for age, sex, hypertension, diabetes mellitus, dyslipidemia, body mass index, smoking status, problem drinking, and antiplatelet use. RESULTS: The adjusted odds ratios (aORs) for the association between H. pylori infection and silent brain infarction and cerebral microbleeds were 1.03 (95% confidence interval [CI], 0.66-1.61) and 0.70 (95% CI, 0.38-1.28), respectively. The aORs for silent brain infarction and cerebral microbleeds were 0.81 (95% CI, 0.44-1.44) and 0.59 (95% CI, 0.30-1.18) in patients aged <65 years and 1.59 (95% CI, 0.78-3.22) and 1.89 (95% CI, 0.38-9.33) in those aged >65 years, respectively. Moreover, the aORs for silent brain infarction and cerebral microbleeds were 0.96 (95% CI, 0.54-1.71) and 0.74 (95% CI, 0.33-1.69) in H. pylori-infected patients without atrophic gastritis and 0.89 (95% CI, 0.48-1.62) and 0.99 (95% CI, 0.43-2.27) in those with atrophic gastritis, respectively. CONCLUSION: No association between H. pylori infection and small vessel disease was observed. H. pylori-induced inflammation may not be a risk factor for microcirculatory damage in the brain.
