New progress in laboratory monitoring of the rivaroxaban therapy
10.3760/cma.j.issn.1009-8158.2019.08.023
- VernacularTitle:利伐沙班治疗监测新进展
- Author:
Jianlong MEN
1
;
Zhenguo ZHAI
;
Jing REN
;
Zhubo ZHANG
Author Information
1. 天津医科大学总医院精准医学中心
- Keywords:
Rivaroxaban;
Chromatography;
liquid;
Tandem mass spectrometr;
Prothrombin time;
Factor Xa;
Clinical laboratory techniques
- From:
Chinese Journal of Laboratory Medicine
2019;42(8):710-716
- CountryChina
- Language:Chinese
-
Abstract:
Rivaroxaban is an oral direct factor FXa inhibitor with predictable pharmacokinetics and no routine monitoring, but the laboratory tests can help to assess the safety and effectiveness of rivaroxaban. The laboratory tests for rivaroxaban include liquid chromatography tandem mass spectrometry (LC-MS / MS), prothrombin time(PT), anti factor Xa activity(anti-Xa), thromboelastography(TEG) and rotational thromboelastography(ROTEM). LC-MS / MS can be used to quantitatively detect the blood concentration of rivaroxaban with good specificity and sensitivity, but the instrument is expensive,technologically complex, and lack standardization, so it belongs to the laboratory developed tests(LDTs).Because of insufficient data of TEG and ROTEM, their clinical performance still needs to be verified. PT can detect "treatment concentration" of rivaroxaban, which can be used as a primary screening method to identify the overdose and the risk of severe bleeding, but the sensitivity of different reagents is different;anti-FXa test can sensitively reflect the change of blood concentration of rivaroxaban, and its clinical efficacy is similar to LC-MS/MS, and therefore it can be used as an effective method to guide doctors to use drugs rationally.
