New developments of microRNAs' modulatory effect on the occurrence and development of atherosclerosis

VernacularTitle:MicroRNA调控动脉粥样硬化发生发展的研究新进展
Author: Chao WANG ¹ ; Xiaofei LIANG ; Xiuru GUAN
Author Information

1. 哈尔滨医科大学附属第一医院检验科150001
Keywords: Atherosclerosis; MicroRNAs; Biomarkers
From: Chinese Journal of Laboratory Medicine 2019;42(6):407-413
CountryChina
Language:Chinese
Abstract: Atherosclerosis(AS) is the basic pathological process of many cardiovascular and cerebrovascular diseases. Particularly, the rupture of vulnerable plaques is a major cause of disability and death among middle-aged and elderly people. It's crucial to find out some reliable serummarkers for diagnosis, treatment and prognosis of AS. This study aims to summarize some newly reported miRNAs which can control the development of AS by regulating the biological function of endothelial cells, smooth muscle cells and macrophages.We also enumerated some target genes and signal pathways that they may act on, and thus provide some new ideas for the treatment of AS and to provide theoretical basis for finding serum biomarkers which can evaluate the occurrence and stability of AS plaque.