The intestinal micro-ecology influences the clinical efficacy of immune checkpoint inhibitors in cancer patients
10.3760/cma.j.issn.1009-9158.2019.05.013
- VernacularTitle:肠道微生态影响肿瘤免疫检查点抑制剂疗效的研究进展
- Author:
Ya'nan ZHOU
1
;
Xiaotong ZHANG
;
Chengjin HU
;
Yuan CAO
Author Information
1. 解放军第九六○医院实验诊断科
- Keywords:
Gastrointestinal microbiome;
Carcinoma,non-small cell lung;
Melanoma
- From:
Chinese Journal of Laboratory Medicine
2019;42(5):386-389
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1 /PD-L1 are increasingly used to treat several types of cancer.Although several agents have been approved,only 10％ to 30％ of patients have benefited from them.Some studies have shown that intestinal micro-ecology can affect the outcome of ICIs through immune regulation in cancer patients.This literature review s summarized the regulation and predictive functions of intestinal micro-ecology on ICIs treatment,and introduced possible mechanisms of intestinal micro-ecology that affacted the efficacy of immunotherapy.In addition,some approaches for detecting gut microbiome were also summarized.Gut microbiota highlighted in this review may serve as novel biomarkers to predict clinical outcomes in cancer patients.
