Prognostic value of plasma big endothelin-1 in patients with moderate to severe chronic ischemic mitral insufficiency after mitral valvuloplasty
10.3760/cma.j.issn.1001-4497.2019.05.010
- VernacularTitle:血浆大内皮素-1对中重度慢性缺血性二尖瓣关闭不全患者二尖瓣成形术后远期预后的预测价值
- Author:
Pengling YU
1
;
Changpeng SONG
;
Baotong LI
;
Bitao XIANG
;
Hengchao WU
;
Hansong SUN
Author Information
1. 北京协和医学院中国医学科学院阜外医院成人心脏外科中心 100037
- Keywords:
Big ET-1;
Ischemic mitral insufficiency;
Mitral valvuloplasty
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2019;35(5):299-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective Big endothelin-1(big ET-1) is associated with the prognosis of various cardiovascular diseases. This study is to explore the predictive value of plasma big ET-1 level for long-term outcome after mitral valvuloplasty in patients with moderate to severe chronic ischemic mitral insufficiency .Methods A total of 142 consecutive patients with moderate to severe chronic ischemic mitral regurgitation who underwent coronary artery bypass grafting and mitral valvuloplasty were enrolled at our center from January 2009 to December 2015.The clinical baseline data were collected and recorded.All patients were followed up.The mortalities and major adverse cardiovascular and cerebrovascular events during the follow-up period were re-corded.Results A total of 142 patients were enrolled, with mean age of(59.4 ±8.3) years.During(51.9 ±22.6) months follow-up, 19 cases(13.4％) died and 35 cases(24.6％) had major adverse cardiovascular and cerebrovascular events.Uni-variate and multivariate Cox regression analysis showed that big ET-1 was an independent risk factor for all-cause mortality (HR=3.970, 95％CI:1.535-10.268) and major adverse cardiovascular and cerebrovascular events(HR=2.754, 95％CI:1.238-6.129).In addition, left ventricular ejection fraction, pulmonary hypertension and stroke history were independent risk factors for all-cause mortality , while left ventricular ejection fraction , stroke history were independent risk factors for major adverse cardiovascular and cerebrovascular events.Conclusion Long-term outcomes of simultaneous coronary artery bypass grafting and mitral valvuloplasty for moderate to severe ischemic mitral insufficiency are satisfactory and big ET-1 is an inde-pendent risk factor for long-term outcomes of these patients.
