Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions.
10.4046/trd.2005.59.5.517
- Author:
Jae Hwa CHO
1
;
Jeong Hyeon NAM
;
Kyum Ho LEE
;
Byeong Kab YOON
;
Jeong Sun RYU
;
Sung Min KWAK
;
Hong Lyeol LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Inha University, Incheon, Republic of Korea. jaehwa.cho@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Matrix metalloproteinase;
Pleural effusion;
Tissue inhibitor of metalloproteinase
- MeSH:
Enzyme-Linked Immunosorbent Assay;
Exudates and Transudates;
Matrix Metalloproteinase 1*;
Peptide Hydrolases;
Pleural Effusion*;
Tissue Inhibitor of Metalloproteinase-1*
- From:Tuberculosis and Respiratory Diseases
2005;59(5):517-521
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions. METHODS: The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay. RESULTS: The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates. CONCLUSION: Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions.
