Advances in novel vaccine adjuvants based on TLR4 agonists

VernacularTitle:基于TLR4激动剂的新型疫苗佐剂研究进展
Author: Qiao LI ¹ ; Yuepeng WANG ; Yusen ZHOU ; Zhihua KOU
Author Information

1. 安徽医科大学研究生学院
Keywords: Adjuvant; Immunostimulant; TLR4; Vaccine
From: Chinese Journal of Microbiology and Immunology 2019;39(8):638-644
CountryChina
Language:Chinese
Abstract: Toll-like receptor 4 (TLR4), a type Ⅰ transmembrane protein, has been extensively studied in the Toll-like receptor family at present. TLR4 ligands include lipopolysaccharides ( LPS) present in the outer membrane of gram-negative bacteria and monophosphoryl lipid A ( MPLA) which is a derivative of LPS. TLR4 agonists, alone, as a major component of compound adjuvants or in combination with other TLRs agonists, have been widely used as adjuvants in various vaccines and demonstrated great potential in vaccine development. This review addressed the discovery, application, features and prospect of novel vac-cine adjuvants based on TLR4 agonists, aiming to provide reference for rational use of adjuvants and further development.