Advance in Shiga toxin
10.3760/cma.j.issn.0254-5101.2019.08.012
- VernacularTitle:志贺毒素研究进展
- Author:
Xi YANG
1
;
Xiangning BAI
;
Yanmei XU
;
Yanwen XIONG
Author Information
1. 中国疾病预防控制中心传染病预防控制所
- Keywords:
Shiga toxin;
Shigella dysenteriae;
Shiga toxin-producing Escherichia coli;
λ-like phage
- From:Chinese Journal of Microbiology and Immunology
2019;39(8):633-637
- CountryChina
- Language:Chinese
-
Abstract:
Shiga toxin (Stx), which can be divided into Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), is an important virulence factor of Shigella spp. and certain strains of Escherichia coli. Stx, enco-ded by λ-like phage, blocks protein synthesis through removal of an adenine residue from the 28S rRNA. Stx can also induce apoptosis through multiple pathways. Humans may suffer from diarrhea, hemorrhagic colitis ( HC) and hemolytic uremic syndrome ( HUS) and even death when infected with Shiga toxin-producing bac-teria. At present, there is no specific treatment for diseases caused by Stx. In recent years, the application of Stx in cancer therapy and imaging has aroused great interest. This review provided a brief overview of Stx in its nomenclature, typing, structure, genetics, pathogenesis and application perspectives.
