Development strategies and application of Fc fusion protein
10.3760/cma.j.issn.0254-5101.2019.07.011
- VernacularTitle:抗体Fc融合蛋白研发策略及应用
- Author:
Fangyuan ZHAO
1
;
Jian WANG
Author Information
1. 国药中生生物技术研究院有限公司第四研究室
- Keywords:
Fc fusion protein;
Protein drug;
Design strategy
- From:
Chinese Journal of Microbiology and Immunology
2019;39(7):551-557
- CountryChina
- Language:Chinese
-
Abstract:
Monoclonal antibodies ( McAb ) , a rapidly expanding class of therapeutic biological products, have been widely used in the treatment of various diseases. Although antibodies have shown tre-mendous clinical value, the breadth and complexity of human diseases urge researchers to constantly develop new drugs with new modes of action rather than to confine them to monoclonal antibodies alone. Fc fusion proteins are becoming a new research hotspot and have shown great potential in the treatment of many human diseases. At present, Fc fusion proteins on the market usually take the interaction between receptors and lig-ands as the main guiding strategy to develop more safer and effective clinical drugs. This article mainly fo-cused on the ligand-receptor interaction as the drug design strategy and the application. of Fc fusion pro-teins.
