Progress in mRNA vaccines against influenza viruses
10.3760/cma.j.issn.0254-5101.2019.05.012
- VernacularTitle:流感病毒mRNA疫苗研究进展
- Author:
Funa LU
1
;
Wenling WANG
;
Xiaoling SHEN
;
Wenjie TAN
Author Information
1. 内蒙古医科大学基础医学院微生物教研室
- Keywords:
Influenza virus;
mRNA vaccine;
Universal influenza vaccine;
Self-amplified mRNA vaccine
- From:
Chinese Journal of Microbiology and Immunology
2019;39(5):396-400
- CountryChina
- Language:Chinese
-
Abstract:
Influenza poses a serious threat to global public health and causes serious economic los-ses. Vaccination is the most effective measure to prevent influenza. However, the mismatch between the vac-cine strain and the epidemic strain, which results from antigenic drift and antigen conversion of influenza vi-rus, often invalidates the conventional vaccine stockpiles. mRNA vaccine is a relatively safe platform com-posed of nucleic acid. Improvements in genetic engineering technology and novel delivery systems have great-ly promoted the research and development of mRNA vaccines against influenza. mRNA vaccines are promis-ing candidates for the rapid and efficient prevention of seasonal influenza epidemics and influenza pandemics.
