Mechanism and cLinicaL characteristics in diagnosis and treatment of amniotic fluid emboLism

VernacularTitle:羊水栓塞的发病机制与临床诊治特点
Author: Alexander LIN ¹ ; Ye FENG ; Yun LU ; Huixia YANG ; Lingqun HU
Author Information

1. 上海嘉会国际医疗妇产科 200233
Keywords: Embolism,amniotic fluid; Mastocytosis; Hypersensitivity
From: Chinese Journal of Perinatal Medicine 2019;22(4):220-222
CountryChina
Language:Chinese
Abstract: Amniotic fluid embolism(AFE) is a fatal intrapartum complication. Typical AFE is characterized by respiratory and circulatory failure, followed by disseminated intravascular coagulation(DIC), while atypical AFE, which had a higher survival possibility, presents with unexplained DIC only. Recent findings support an anaphylactoid inflammatory mechanism underlying the pathophysiology of AFE. Milrinone is currently the first choice for AFE due to its several functions, such as reducing pulmonary artery pressure, and improving right ventricular function through lowering heart rate and positive inotropic action. A multidisciplinary team is required in the rescue of AFE and medical staff who are skilled in critical medicine (such as anesthesiologists) often play a pivotal role.