Research progress of von Willebrand factor for prevention and treatment of ischemic stroke

VernacularTitle:血管性血友病因子在缺血性脑卒中防治中的研究进展
Author: Bin YAN ¹ ; Shiqi LU ; Yiming ZHAO
Author Information

1. 郑州大学附属南阳市中心医院检验科 473000
Keywords: Von Willebrand factor; Stroke; Targets
From: Chinese Journal of Neurology 2019;52(9):780-786
CountryChina
Language:Chinese
Abstract: Von Willebrand Factor (VWF) is a multimeric glycoprotein produced by endothelial cells, which increases in thrombogenicity especially under high shear rates. It bridges between vascular platelets and sub?endothelial collagen. There is abnormal VWF level in ischemic stroke patients, and VWF shows unique significance in valuing the prediction, treatment and prognosis of ischemic stroke. Numerous basic and clinical evidences suggest that VWF is a potential target for ischemic stroke treatment. In recent years, researches on VWF for prevention and treatment of ischemic stroke have been rapidly developed. The findings in this field are reviewed in this paper.