The effect of butylphthalide injection combined with interventional therapy on patients with acute anterior circulation large vessel occlusive stroke
10.3760/cma.j.issn.1006-7876.2019.07.007
- VernacularTitle:丁苯酞氯化钠注射液联合介入治疗急性前循环大血管闭塞性卒中患者的疗效观察
- Author:
Feihong HUANG
1
;
Lulu XIAO
;
Shun LI
;
Rui SUN
;
Danlei CHEN
;
Wen SUN
;
Yunfei HAN
;
Minmin MA
;
Qin YIN
;
Ruibing GUO
;
Wusheng ZHU
;
Xinfeng LIU
Author Information
1. 南方医科大学南京临床医学院(东部战区总医院)神经内科
- Keywords:
Acute ischemic stroke;
Large vessel occlusion;
Endovascular treatment;
Functional outcome;
Butylphthalide;
Propensity score-matched analyses
- From:
Chinese Journal of Neurology
2019;52(7):555-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of butylphthalide and sodium chloride injection on patients who received endovascular treatment for acute anterior circulation large vessel occlusive stroke.Methods A total of 173 patients were identified from February 2015 to December 2017 in the Department of Neurology of Jingling Hospital in this retrospective observational study.Propensity score-matching analysis was performed to balance differences in baseline characteristics between patients who received butylphthalide injection (butylphthalide group) and those who did not (control group).The modified Rankin Scale scores at 90 days were compared between the butylphthalide and control groups.Results A total of 144 patients who received endovascular treatment for acute anterior circulation large vessel occlusive stroke were finally analyzed,54 cases in the butylphthalide group and 90 cases in the control group.The proportion of good functional outcome at 90 days in the butylphthalide group was higher than that in the control group (63.0％ (34/54) vs 44.4％ (40/90);x2=4.633,P=0.031).Thirty-six pairs were matched successfully by the propensity score matching,36 patients in the butylphthalide group and 36 in the control group.There was no statistically significant difference in the 90-day functional outcome between the two groups (66.7％ (24/36) vs 44.4％ (16/36);x2=3.600,P=0.058).One hundred and fifteen patients were recanalized,47 cases in the butylphthalide group and 68 cases in the control group,and after the propensity score matching,30 pairs were analyzed.The proportion of good functional outcome at 90 days in the butylphthalide group was higher than that in the control group (73.3％ (22/30) vs 46.7％ (14/30);x2=4.444,P=0.035).Conclusion After propensity score-matching,butylphthalide and sodium chloride injection could improve 90-day functional outcome in patients with acute anterior circulation large vessel occlusive stroke and obtained recanalization by endovascular treatment while could not before propensity score-matching.
