Efficacy of levothyroxine on benign thyroid nodules and its effect on blood lipids
10.3760/cma.j.issn.1671?7368.2019.07.014
- VernacularTitle:左甲状腺素治疗良性甲状腺结节的效果及对血脂的影响
- Author:
Yifen LIU
1
;
Changheng YIN
;
Guangyuan ZHAO
;
Jiuju ZHANG
;
Linna WANG
;
Suhua HOU
;
Baoheng ZHENG
Author Information
1. 哈励逊国际和平医院普外一科
- Keywords:
Thyroxine;
Thyroid nodule;
Treatment outcome
- From:
Chinese Journal of General Practitioners
2019;18(7):679-681
- CountryChina
- Language:Chinese
-
Abstract:
Three hundred and nine patients with thyroid nodules detected by physical examination in Harrison International Peace Hospital from October 2013 to October 2017 were divided into intervention group (155 cases) and control group (154 cases). Patients in intervention group received oral levothyroxine sodium 25 g / d for 12 months and those in control group had no treatment, patients were followed up every 3 months to 12 months. After treatment, the maximum diameter and thyroid nodule volume of the intervention group were (31.87±3.84) mm and (17.32±0.94) cm3, which were significantly smaller than those of the control group [(34.01±3.72) mm and (24.25±1.21)cm3, P<0.05]. TSH in intervention group was lower than that in control group [(2.24±0.41) vs. (2.52±0.58) mIU/L, P<0.05] and free T4 (FT4) was higher than that in control group [(25.64 ± 3.85) vs. (16.39 ± 3.28) pmol/ L, P<0.05]. TC, TG and LDL?C in intervention group, were lower than those in the control group .The HDL?C level in intervention group was higher than that in control group (all P<0.05). After treatment, there were no malignant changes in the intervention group, while the malignant change rate in control group was 2.6％ (4/154). It is suggested that levothyroxine treatment can reduce TSH level in patients with benign thyroid nodules, inhibit the growth of thyroid nodules.
