Association of vitamin D level and vitamin D receptor gene FokI polymorphisms in pregnant women with fetal growth restriction
10.3760/cma.j.issn.1671-7368.2019.07.012
- VernacularTitle:孕妇血维生素D及其受体FokI基因多态性与胎儿生长受限的相关性研究
- Author:
Zhihui WANG
1
;
Xinxiao CHEN
;
Xuna SHEN
;
Qinjian YU
;
Wenjing BAI
;
Huanzheng LI
;
Zejiao FENG
Author Information
1. 温州市中心医院妇产科 325000
- Keywords:
Fetal growth retardation;
Vitamin D;
Receptors,vitamin D;
Genes
- From:
Chinese Journal of General Practitioners
2019;18(7):672-675
- CountryChina
- Language:Chinese
-
Abstract:
Serum vitamin D level and vitamin D receptor (VDR) gene FokI polymorphisms were detected in 200 single full-term pregnant women who gave birth in our hospital during 2016 to 2018. The newborns with birth weight<2500 g were diagnosed as fetal growth restriction (FGR), there were 100 cases in FGR group and 100 cases in control group. The average level of vitamin D in pregnant women in FGR group was significantly lower than that of the control group [(30.1±10.9) vs. (36.1±15.8) nmol/L, P<0.05]. In the FGR group, the birth weight of infants in mother carrying ff genotype was significantly lower than that in mother carrying Ff and FF genotypes [(2073±90) g vs. (2242±122) g and (2349±96) g, P<0.05]. Pregnant women carrying Ff and FF genotypes had lower risk of FGR than those of carrying ff genotype (ORFf=0.31, 95％ CI: 0.17-0.76; ORFF=0.28, 95％CI: 0.11-0.46). The pregnant women with serum 25(OH)D level>30 nmol/L carrying F allele (FF+Ff) were set as reference, the risk of FGR in pregnant women with serum 25 (OH)D level ≤ 30 nmol/L carrying ff genotype was increased (OR=6.14, 95％CI: 2.13-13.23). The polymorphism of VDR gene FokI may be associated with the occurrence of FGR. In the case of vitamin D deficiency, the influence of ff genotype on FGR is more tangible.
