Factors influencing antibiotics dosage adjustment in continuous renal replacement therapy
10.3760/cma.j.issn.1671-7368.2019.06.023
- VernacularTitle:连续性肾脏替代治疗对抗菌药物剂量调整影响因素的研究进展
- Author:
Qi LIU
1
;
Ruihua WANG
Author Information
1. 山西医科大学第一临床医学院
- Keywords:
Continuous renal replacement therapy;
Anti-bacterial agents;
Influencing factors
- From:
Chinese Journal of General Practitioners
2019;18(6):600-603
- CountryChina
- Language:Chinese
-
Abstract:
Continuous renal replacement therapy (CRRT) will eliminate antibiotics while eliminating water and solutes from the body,so adjusting antibiotics dose timely is important for patients undergoing CRRT.Pharmacological characteristics of antimicrobials,pathological and physiological statues of the patients,effects of CRRT on antibiotics clearance and other factors would affect the pharmacokinetics of antibiotics.In order to achieve the desired therapeutic effect,the monitoring of drug concentration and individualizing the dosage of antibiotics are cecessary.
