Laminin may be a predictor of recurrence after liver transplantation for HBV -related hepatocellular carcinoma patients
10.3760/cma.j.issn.0254-1785.2019.05.010
- VernacularTitle:层粘连蛋白预测HBV感染相关性肝癌肝移植术后肿瘤复发的临床意义
- Author:
Chao FENG
1
;
Lihong HUANG
;
Peixiao WANG
;
Ping SUN
;
Xinguo CHEN
;
Zhongyang SHEN
;
Qing ZHANG
Author Information
1. 中国人民解放军总医院第三医学中心肝脏移植科
- Keywords:
Hepatocellular carcinoma;
Hepatitis B virus;
Liver transplantation;
Laminin
- From:
Chinese Journal of Organ Transplantation
2019;40(5):298-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic role of laminin (LN ) as a tumor biological marker in predicting the recurrence of hepatocellular carcinoma (HCC) related with HBV infection after liver transplantation (LT ) .Methods Tissue samples from 251 HBV-related HCC patients undergoing LT were immunohistochemically stained with anti-LN antibody .The relevant prognostic factors were analyzed using Spearman's rank test , Kaplan-Meier method , log-rank test and multivariate step-wise Cox regression analysis .Results The expressions of LN in tumor tissues were significantly positively correlated with tumor number (P=0 .00) ,microsatellite (P=0 .02) ,venous invasion (P=0 .048) ,pTNM tumor stage (P=0 .00) ,pre-LT serum α-fetoprotein (AFP) level (P=0 .00) ,HBV DNA level (P= 0 .02) ,HBeAg level (P= 0 .02) and tumor recurrence (P= 0 .00) respectively .Significant differences existed in 1/3/5-year overall survival or tumor recurrence-free survival rate post-LT among LN different expression (-,+ ,≥ + + ) in HBV-related HCC patients (P< 0 .05 ) . Multivariate analysis indicated that LN was a significantly independent predictor in predicting poor tumor recurrence-free survival post-LT (P=0 .01) .Conclusions LN may be a feasible marker in predicting HCC recurrence post-LT for HBV-related HCC patients .
