Simultaneous pancreas and kidney transplantation for 5 patients with diabetesplus end-stage renal disease
10.3760/cma.j.issn.0254-1785.2019.05.004
- VernacularTitle:胰肾联合移植治疗糖尿病肾功能衰竭五例临床分析
- Author:
Shengsheng REN
1
;
Liangliang XU
;
Turun SONG
;
Ming ZHANG
;
Tao LIN
;
Mingqing XU
;
Shifeng LI
Author Information
1. 四川大学华西医院器官移植中心
- Keywords:
Simultaneous pancreas and kidney transplantation (SPK);
Diabetes;
End-stage renal disease;
Perioperative management
- From:
Chinese Journal of Organ Transplantation
2019;40(5):272-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reduce the perioperative complications of simultaneous pancreas and kidney transplantation (SPK ) and boost the clinical efficacy by exploring its perioperative management in diabetics with end-stage renal disease .Methods Retrospective analysis was performed for the clinical data of 5 diabetics with end-stage renal disease undergoing SPK since 2017 .Results The cold ischemic time of all allografts was under 8 hours .No surgical complications occurred in recipients post-transplantation .Two patients were complicated with hyperkalemia and their serum potassium levels normalized after treatment .One case of bleeding in abdominal cavity was cured conservatively . Renal functions of two patients with delayed renal function post-transplantation gradually recovered after hematodialysis . One case of peritransplant fluid collection recovered after debridement and drainage .Another case of acute left heart failure and cardiac arrest at 45 days post-transplantation resumed normal heart rhythm after rescue .However ,his consciousness could not be restored and his families gave up subsequent treatments . Transplanted kidneys and pancreases of these 4 patients normalized .Follow-up was conducted until March 20 , 2019 . They became insulin and dialysis independent and serum creatinine and blood glucose normalized .Diabetic complications were relieved and their quality-of-life also improved significantly .Conclusions SPK is an effective treatment for diabetics with end-stage renal disease .While maintaining normal serum creatinine and blood glucose , it may liberate patients from insulin dosing and dialytic maintenance ,lower diabetic complications and improve quality-of-life .
