Clinical prognostic significance of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
10.3760/cma.j.issn.0254-1785.2019.03.006
- VernacularTitle:allo-HSCT早期淋巴细胞恢复对急性髓系白血病预后的临床意义
- Author:
Wenyi GUO
1
;
Weijie CAO
;
Xinsheng XIE
;
Rong GUO
;
Suping ZHANG
;
Li LI
;
Ran YAN
;
Dingming WAN
Author Information
1. 郑州大学第一附属医院造血干细胞移植中心 450052
- Keywords:
Allogeneic hematopoietic stem cell transplantation;
Acute leukemia;
lymphocyte
- From:
Chinese Journal of Organ Transplantation
2019;40(3):148-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical significance of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute myeloid leukemia.Methods The clinical data of 89 patients with acute myeloid leukemia undergoing allo-HSCT were retrospectively analyzed.The absolute lymphocyte count at Day 21 (ALC21) after allo-HSCT was used for representing the recovery rate of lymphocyte.And the effects of ALC21 on disease relapse,overall survival (OS),disease-free survival (DFS) and other parameters were analyzed.Results The recurrent rate of ALC21 ≥0.5 × 109/L group (high ALC21 group) was significantly lower than that of ALC21 ＜0.5× 109/L group (low ALC21 group) (19.6 ％ vs 48.5 ％,P=0.004).The 2-year OS and DFS of high ALC21 group spiked markedly as compared with low ALC21 group [(74.0 ± 6.0 ％ vs (46.5±9.5) ％,P=0.002],[(70.5 ± 6.2) ％ vs (44.9±9.3) ％,P =0.009] while viral infection rate declined markedly (37.5 ％ vs 60.6 ％,P =0.035).However,non-recurrence mortality (NRM),acute graft-versus-host disease (aGVHD) and chronic graft-versus-host disease (cGVHD) (P =0.556) were not elevated in high ALC21 group as compared with low ALC21 group (P=0.584,P =0.08,P =0.556).Conclusions Early lymphocyte recovery after in acute myeloid leukemia patients has significant early predictive value for recurrence and long-term prognosis after allo-HSCT.
