Hematopoietic stem cell transplantation for Ph-like acute lymphoblastic leukemia and literature review
10.3760/cma.j.issn.0254-1785.2019.03.005
- VernacularTitle:造血干细胞移植治疗Ph样急性淋巴细胞白血病五例报道并文献复习
- Author:
Haiping DAI
1
;
Zheng LI
;
Jia YIN
;
Minghong LIU
;
Xiaming ZHU
;
Depei WU
;
Xiaowen TANG
Author Information
1. 苏州大学附属第一医院血液科江苏省血液研究所卫生部血栓与止血重点实验室血液学协同创新中心
- Keywords:
Heamatopoietic stem cell transplantation;
Lymphoblastic leukemia;
Acute
- From:
Chinese Journal of Organ Transplantation
2019;40(3):144-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of hematopoietic stem cell transplantation (HSCT) for 5 patients with Ph-like acute lymphoblastic leukemia (ALL).Methods Fluorescent in situ hybridization (FISH) was performed for detecting the rearrangement of susceptibility genes.Combined therapy of chemotherapy and ruxolitinib were applied,followed by HSCT.Those failing to achieve complete remission (CR) received an infusion of chimeric antigen T-cells (CAR-T),followed by HSCT once CR was achieved.Four patients accept allogenic HSCT while another auto HSCT.Results Three of them achieved CR after chemotherapy and ruxolitinib.The remaining 2 patients got CR after CAR-T.Four patients remained in CR after HSCT.Early relapse occurred in 1 patient after HSCT.Conclusions Combined therapy of chemotherapy,ruxolitinib and CAR-T are necessary for Phlike ALL patients.HSCT after an initial CR improve patient prognosis.
