BK virus infection and urothelial carcinoma after renal transplantation
10.3760/cma.j.issn.0254-1785.2019.02.008
- VernacularTitle:BK病毒感染与肾移植术后尿路上皮癌发生的相关性研究
- Author:
Shijie YAO
1
;
Guangming LIU
;
Lei XU
;
Yuliang WANG
;
Hongshun MA
Author Information
1. 天津市第一中心医院泌尿外科 300192
- From:
Chinese Journal of Organ Transplantation
2019;40(2):98-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential role of BK virus (BKV) in urothelial carcinoma after renal transplantation .Methods From May 2013 to March 2017 , We collected 26 cases of urothelial carcinoma after renal transplantation (study group) and 30 cases of urothelial carcinoma of non-immunosuppressed patients (control group) .Tumor tissues were stained with SV40 T antigen by immunohistochemical assay .Urinary and peripheral blood samples were assayed for BKV-DNA levels by real-time fluorescent quantitative polymerase chain reaction (PCR) .Results There were 7 positive cases of SV40 T-Ag in study group and only 1 weakly positive case in control group .The positive rate of BKV-DNA was 38 .5％ in urinary samples in study group (10 /26 ) and it was significantly higher than that in control group by 10％ (3/30)(P< 0 .05) .And the positive rate of blood BKV-DNA was not different between two groups ( P > 0 .05 ) .Conclusions There is a relatively high prevalence of BKV infection in urothelial carcinoma after renal transplantation .And a ,high level of BKV infection may play a role in urothelial carcinoma after renal transplantation .
