Clinical efficacy and application criteria of single kidney transplantation from pediatric donors
10.3760/cma.j.issn.0254-1785.2018.07.004
- VernacularTitle:儿童单侧供肾成人肾移植的临床疗效
- Author:
Mengqin WANG
1
;
Xia LU
;
Jing XU
;
Changsheng MING
;
Jipin JIANG
;
Zhishui CHEN
;
Zhonghua CHEN
;
Nianqiao GONG
Author Information
1. 华中科技大学同济医学院附属同济医院器官移植研究所 国家卫生和计划生育委员会器官移植重点实验室 器官移植教育部重点实验室 中国医学科学院器官移植重点实验室
- Keywords:
kidney transplantation;
pediatric donor;
single kidney donor
- From:
Chinese Journal of Organ Transplantation
2018;39(7):397-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical outcome of single kidney transplantation from pediatric donors and to explore the application criteria.Methods The clinical data of 14 recipients undergoing renal transplantation from October 2006 to October 2016 were retrospectively analyzed.All the recipients received primary kidney transplantation from pediatric donor and the renal artery was anastomosed with external iliac artery.Based on the length of the kidney donor,the recipients were divided into two groups as group A (length beyond 6 cm) and group B (length 5-6 cm).The clinical effect and complications of the 14 recipients,the survival of the recipients and grafts,the recovery of renal function,the change of the renal length and the postoperative complications were compared between the two groups.Results The renal length in group A (n =7) was (7.5 ± 1.2) cm,and (5.7 ± 0.1) cm in group B (n =7).During the follow up period,all renal grafts and recipients survived.No significant difference was observed between two groups in renal graft function evaluated by serum creatinine and estimated glomerular filtration rate (eGFR) at 7th day,14th day,1st,2nd,3rd and 6th month postoperatively,P＞0.05.The length of transplanted kidney increased after operation in both groups,with results of 9.9 ± 0.6 cm in group A and 10.4 ± 1.5 cm in group B (P＞0.05),respectively,at 2nd month post-transplantation.Delayed graft function (DGF) occurred in 2 cases of group A and 1 case of group B.Seven cases developed proteinuria (50.0％),including 2 cases in group A (28.6％) and 5 cases in group B (71.4％).Four cases suffered hematuria (28.6％),including 2 cases in group A (28.6％) and 2 cases in group B (28.6％).One recipient in group B suffered acute rejection.No vascular embolization,urine leakage,pulmonary infection and other complications were observed in all the recipients.Conclusion The length beyond 5 cm is acceptable for single pediatric kidney donor for adult recipients with a promising clinical outcome in short-term.However,the high incidence of proteinuria and hematuria remains obstacle,and the long-term outcome needs further exploration.
