Endotoxin and intestinal microflora in patients with hepatocellular carcinoma
10.3670.cma.j.issn.1007-631X.2019.08.011
- VernacularTitle:原发性肝癌患者内毒素与肠道菌群变化的相关性研究
- Author:
Hairong XIN
1
;
Xi LI
;
Ruifang SUN
;
Yongsheng MENG
;
Qianqian YU
;
Yuxia HAO
Author Information
1. 山西省肿瘤医院普外二病区
- Keywords:
Carcinoma,hepatocellular;
Enterobacteriaceae;
Bifidobacteriales infections;
Endotoxins
- From:
Chinese Journal of General Surgery
2019;34(8):686-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of endotoxin in blood,Escherichia coli,lactobacillus,bifidobacterium,enterococci in feces of HCC patients.Methods Real-time fluorescence quantitative PCR was used to detect the difference between HCC group and normal group in the expression in bifidobacterium,lactobacillus,enterococcus and Escherichia coli,and the difference of endotoxin level.Results The expression levels of Escherichia coli and enterococcus in HCC group were significantly higher than those in normal control group (P＜ 0.05).Bifidobacterium and lactobacillus in primary liver cancer group significantly decreased compared with the normal group (P ＜ 0.05).The serum endotoxin level in HCC group was significantly higher than that in normal control group (P ＜ 0.05).Bifidobacterium and lactobacillus increased in HCC group.Enterococcus and escherichia coli decreased in HCC group.There was a significant positive correlation between endotoxin content and tumor number and tumor diameter in HCC patients.Conclusion Bifidobacterium,lactobacillus decreased,enterococcus and Escherichia coli increased in HCC patients.These changes along with the increase of endotoxin may relate to the development of HCC.
