Newly developed nonalcoholic fatty liver disease after pancreaticoduodenectomy
10.3760/cma.j.issn.1007-631X.2019.08.006
- VernacularTitle:胰十二指肠切除术后新发非酒精性脂肪肝的危险因素及对生存的影响
- Author:
Jiuxing DONG
1
;
Jinmeng HU
;
Kaili ZHAO
;
Song GAO
;
Weiwei BAI
;
Jian WANG
Author Information
1. 天津医科大学肿瘤医院胰腺肿瘤科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心 天津300060
- Keywords:
Pancreatoduodenectomy;
Fatty liver;
Risk factors;
Survival analysis
- From:
Chinese Journal of General Surgery
2019;34(8):667-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study risk factors of newly developed nonalcoholic fatty liver disease (NAFLD) in patients after pancreaticoduodenectomy (PD) and the effect on prognosis.Methods Date of patients undergoing PD surgery at Pancreatic Department,Tianjin Cancer Hospital were collected from Jan 2016 to Dec 2016.Patients were divided into two groups according to occurrence of NAFL Devents.Results There were 22 patients in NAFLD group (group Ⅰ) and 47 patients in non NAFLD group(group Ⅱ).All patients were followed up till the end of 2017.Multi-factor analysis showed that extraintestinal drainage of pancreatic juice (OR =18.118,95％ CI 2.968-114.455,P =0.002) and dissected lymph node number over 30 (OR =8.424,95％ CI 2.272-31.232,P =0.001) were independent factors associated with NAFLD in patients after PD.Survival analysis showed no statistically significance for median progression-free survival (12.7 months in group Ⅰ vs.13.9 months in group Ⅱ,P =0.99) and median overall survival (mOS) (15.4 months in group Ⅰ vs.17.7 months in group Ⅱ,P =0.09).Conclusions Extraintestinal drainage of pancreatic juice and lymph node clearance over 30 are independent risk factors for new NAFLD in PD patients.The effect of new NAFLD on PFS and OS is not statistically significant.
