The effect of neovascularization in carotid plaque on clinical manifestations
10.3760/cma.j.issn.1007-631X.2019.06.013
- VernacularTitle:颈动脉斑块内新生血管的临床意义
- Author:
Yiyao CUI
1
;
Xiaoshuo LYU
;
Jianyan WEN
;
Peng LIU
;
Lin PAN
;
Feng WANG
;
Xueqiang FAN
;
Zhidong YE
Author Information
1. 中国医学科学院北京协和医学院研究生院
- Keywords:
Endarterectomy,carotid;
Arteriosclerosis;
Stroke;
Neovascularization
- From:
Chinese Journal of General Surgery
2019;34(6):520-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of angiogenesis in carotid atherosclerotic plaque.Methods From Jan 2016 to Aug 2016,Carotid artery plaque was abtained in 52 cases after carotid endarterectomy at the Department of Cardiovascular Surgery of China-Japan Friendship Hospital.Patients were divided into symptomatic group and asymptomatic group.Specimens were stained with HE and Movat,and the density,size,distribution and morphology of neovascularization were counted.Results The density of neovascularization in the symptomatic group and the asymptomatic group were 5.27 ± 0.46 and 2.30 ±0.29,respectively (P ＜ 0.001),the average cross-sectional area of neovascularization in the symptomatic group was (2.26±0.21) mm2 and (1.00 ±0.48) mm2 in the asymptomatic group (P=0.02).In the distribution,the symptomatic group and the asymptomatic group were 3.37 ± 0.46/ mm2,1.32 ±0.16/mm2 in basal part,3.71 ±0.42/mm2,1.56 ±0.20/mm2 in the shoulder part,3.48 ±0.44/mm2,1.55 ± 0.21/ mm2 in the fibrous cap,respectively (P ＜ 0.001).Conclusion The density and cross-sectional area of neovascularization in the symptomatic group were larger than those in the asymptomatic group,irregular branching vessels were dominant.
