Progression-free survival related factors and the prognosis after first surgical resection for retroperitoneal liposarcoma
10.3760/cma.j.issn.1007-631X.2019.05.004
- VernacularTitle:腹膜后脂肪肉瘤患者首次外科切除后无进展生存期的影响因素及预后分析
- Author:
Mingke HUO
1
;
Guangsen HAN
;
Yingkun REN
;
Yong CHENG
;
Jian YANG
Author Information
1. 郑州大学附属肿瘤医院普外科(河南省肿瘤医院普外科) 450008
- Keywords:
Liposarcoma;
Disease-free survival;
Prognosis;
Surgical procedures,operative
- From:
Chinese Journal of General Surgery
2019;34(5):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the first surgical treatment on progression-free survival (PFS)time of retroperitoneal liposarcoma and the prognosis.Methods We analyzed the clinical data of 74 cases of retroperitoneal liposarcoma from 1998 to 2016 in He'nan Cancer Hospital (Zhengzhou University Affiliated Tumor Hospital Department of General Surgery).Results The results demonstrated that progression-free survival time of the first surgical resection of retroperitoneal liposarcoma in patients related with tumor necrosis (P ＜ 0.001),lobulated tumor (P ＜ 0.001),symptoms (P =0.013),Ro resection (P =0.003),distant metastasis (P =0.028),postoperative chemotherapy (P =0.006) and tumor differentiation (P ＜ 0.001).Progression-free survival time was not correlated with gender,age of first diagnosis,the invasion of adjacent organs,tumor size,operation time and combined organ resection (all P＞0.05).The rate of 1-year,3-year,5-year survival time attached to PFS≤24 m and PFS ＞24 m were 93.7％ vs.94.7,90.5％ vs.80.9％,58.4％ vs.74.8％(P=0.111).Conclusion The first attempt of radical resection determines progression-free survival of retroperitoneal liposarcoma,however,patients' PFS was not related with their overall survival.
